Dr. Bonni Goldstein, MD

---

Minor Cannabinoids: Mechanisms and Emerging Clinical Potential

Dr. Bonni Goldstein, MD, CEO & Co-founder, Goldstein Wellness 

While Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have dominated both research and clinical discourse, the cannabis plant produces a diverse array of lesser-known “minor cannabinoids” with distinct pharmacologic profiles and emerging therapeutic potential. Compounds such as cannabigerol (CBG), cannabidivarin (CBDV), cannabidiolic acid (CBDA), and others are largely non-intoxicating and demonstrate meaningful biologic activity across multiple receptor systems beyond CB1 and CB2, including TRP channels, PPARs, and serotonergic pathways.

Preclinical data suggest these cannabinoids possess potent anti-inflammatory, neuroprotective, analgesic, and anticonvulsant properties. Early clinical observations and case-based reports further support their potential utility in conditions such as chronic pain, inflammatory disorders, neurodegenerative disease, and mood dysregulation. 

This session will provide an overview of the mechanisms of action of key minor cannabinoids, review the current state of translational and clinical evidence, and discuss real-world clinical experiences. As research advances, minor cannabinoids are poised to play an increasingly significant role in precision cannabinoid therapeutics.

Bonni Goldstein, MD is the Medical Director of Canna-Centers Wellness & Education, a leading cannabis medicine specialty practice in Los Angeles, and the CEO of GoldsteinWellness.com, an educational platform dedicated to helping licensed healthcare professionals incorporate medical cannabis and hemp into their practices. After years in the field of pediatric emergency medicine, in 2008 she became interested in the science of medical cannabis following the profound improvements she witnessed in a seriously ill friend using cannabis, and has since evaluated thousands of patients for medical cannabis treatment. She has co-authored numerous papers on the use of pharmacometabolomics to study the impact of medical cannabis on the behavioral symptoms associated with autism. Dr. Goldstein is the author of the book Cannabis is Medicine: How Medical Cannabis and CBD are Healing Everything from Anxiety to Chronic Pain. She is a medical advisor to numerous companies, including Cannformatics, Neurotech International LLC, and Weedmaps.